Studies towards the total synthesis of lactacystin and its derivatives

  • 3.79 MB
  • 8260 Downloads
  • English
by
Statementby Ahmad Sazali Hamzah.
ID Numbers
Open LibraryOL18425793M

A total synthesis of the novel neurotrophic agent (+)-lactacystin (1) has been achieved in 11 steps and 14% overall yield from (2R,3S)hydroxyleucine [(+)]. The construction and bioassay of several active analogs are also by: Studies towards the total synthesis of lactacystin and its derivatives Author: Hamzah, Ahmad Sazali ISNI: The first chapter contains a review of the total synthesis of lactacystin and also its derivatives.

Chapter two consists of our own synthetic work, and experimental details are provided in chapter : Ahmad Sazali Hamzah. Studies on the total synthesis of lactacystin.

Details Studies towards the total synthesis of lactacystin and its derivatives FB2

An improved aldol coupling reaction and a β-lactone intermediate in thiol ester formation. Tetrahedron Letters34 (44), Cited by: This thesis consists of four chapters. The first contains a literature review of the isolation, previous total syntheses, biological activity and structure activity relationships of lactacystin and its analogues.

Chapter two discusses our work towards the total synthesis of lactacystin and its analogues starting from three different amino : Alexandra Horton. Title:A Review of the Total Synthesis of (+)-Lactacystin and its Analogs VOLUME: 19 ISSUE: 20 Author(s): David Malinak, Jozef Gonda, Jan Korabecny, Rafael Dolezal, Jan Honegr, Ondrej Soukup, Marek Buzga and Kamil KucaCited by: 3.

A total synthesis of the novel neurotrophic agent (+)-lactacystin (1) has been achieved in 11 steps and 14% overall yield from (2R,3S)hydroxyleucine [(+)]. The construction and bioassay of several active analogs are also described.

A Review of the Total Synthesis of (+)-Lactacystin and Its Analogs Article (PDF Available) in Current Organic Chemistry 19(20) August with Reads How we measure 'reads'. Stereoselective synthesis of highly functionalized spirocyclic compounds based on a Claisen rearrangement and its application to the synthesis of natural products: 08YGK The syntheses and applications of β-benzylmercaptoethylamine derivatives, particularly, in the chemistry of heterocycles and natural products: 09T   Lactacystin exemplifies the role that serendipity plays in drug discovery and why “finding things without actually looking for them” retains such a pivotal role in the search for the useful Cited by: 1.

TETRAHEDRON LETTERS Pergamon Tetrahedron Letters 40 () Studies towards the total synthesis of halichlorine: asymmetric synthesis of the spiroquinolizidine subunit t Dirk Trauner "-* and Samuel J. Danishefsky ~b aLaboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, York Ave.,Cited by: A total synthesis of the novel neurotrophic agent (+)-lactacystin (1) has been achieved in 11 steps and 14% overall yield from (2R,3S)hydroxyleucine [(+)].

The construction and bioassay of. TOTAL SYNTHESIS OF (+)-LACTACYSTIN AND ITS DERIVATIVES Corey synthesis The first total synthesis of 1 was published by Corey and Reichard in [42]. L-serine methyl ester (10) was. A Comparative Study of Synthetic Approaches Towards Total Synthesis of Mandelalide A, An Anti-Lung Cancer Metabolite From Lissoclinum Ascidian.

Author(s): Ghulam Shabir, Aamer Saeed*.Cited by: 1. Book Series Help; Contact Portal SYNTHESIS Full-text search Ethenesulfonyl Fluoride (ESF) and Its Derivatives in SuFEx Click Chemistry and More Studies towards the Total Synthesis of Kadcotrione B Full Text HTML.

As part of our studies directed towards a total synthesis of lactacystin, we have developed a reliable and environmentally acceptable method to oxidise 2,2,4-trisubstituted 3-pyrrolines to the. Studies on the total synthesis of lactacystin.

An improved aldol coupling reaction and a β-lactone intermediate in thiol ester formation select article A stereoselective synthesis of 3,3-disubstituted allylborane derivatives using haloboration reaction and their application for the diastereospecific synthesis of homoallylic alcohols having.

Furthermore, the total synthesis (+)-stemoamide (1) via a novel dyotropic rearrangement of 3,4-cis-β-lactone was also explored. Albeit this route failed to attain the intended objective, the experimental results shed light on the substrate limitation of the dyotropic rearrangement of 3,4- cis - β -lactone, which prompted us to devise an alternative strategy to achieve the by: 4.

Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first identified as an inducer of neuritogenesis in neuroblastoma cells in The target of lactacystin was subsequently to be to the proteasome on the basis for its affinity to certain catalytic subunits of the proteasome by Fenteany and co Acidity (pK): Total synthesis and biological activity of lactacystin, omuralide and analogs.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MassachusettsUSA. Lactacystin (1) and the related beta-lactone omuralide (2) are remarkably selective and potent irreversible inhibitors of the 20 S proteasome, a large Cited by: The 26S proteasome inhibitor (+)-lactacystin (1)1, 2 has been the subject of much synthetic interest and a wide variety of strategies have been employed for its preparation.

3 Stereoselective construction of the embedded α,α-dialkyl-α-amino acid moiety is an essential step in any synthesis of 1, and we found it surprising that direct functionalization of proline (or proline derivatives) at Cited by: 5. A scalable total synthesis of the potent proteasome inhibitor salinosporamide A is reported that proceeds in 16 steps and 5 % overall yield and features an oxidative radical cyclization as a key step.

Studies Towards the Total Synthesis of Nagstatin [abstract] 11) J Robertson, M A Peplow, J Pillai, Tetrahedron Lett.

Download Studies towards the total synthesis of lactacystin and its derivatives EPUB

37, The Synthesis of (±)-Heliotridane and (6S,7S)-Dihydroxyheliotridane via Sequential Hydrogen Atom Abstraction and Cyclisation 10) J Robertson, G O’Connor, D S Middleton, Tetrahedron Lett.

37, An Enantioselective Formal Synthesis of (+)-Lactacystin from Hydroxymethyl Glutamic Acid (HMG) Progress towards the Total Synthesis of Scytonemin A: Asymmetric Synthesis of (2S,3R,4R) Studies towards the Taming of the ‘Carbocation’ in the Regioselective Ring Opening of Epoxides to Allylic Alcohols.

DERIVATIVES by Yan Mei A thesis submitted in partial fulfillment The first total synthesis of OSW-1 6 Jin approach for the total synthesis of OSW-1 7 CHAPTER 5 MODEL STUDY TOWARDS THE TOTAL SYNTHESIS OF ANTICANCER NATURAL PRODUCT SUPERSTOLIDE A 99 Introduction: Superstolides A and B A new process is described for metal-catalyzed doubly diastereoselective Mukaiyama aldol coupling of a chiral tertiary α-amino aldehyde and an achiral silyl enol ether to form selectively an anti-aldol product.

The metal requirement is strict, since of several salts tested only MgI2 functions as an effective catalyst. The MgI2-catalyzed aldol greatly facilitates the total synthesis of. Efforts towards the total synthesis of desmethylprehelminthosporol by: Gulacsy von Gulacs, Christina Elizabeth.

Progress studies toward a total synthesis of the minimized analogs, desisopropyl- and desmethylene-prehelminthosporol, of the phytotoxin prehelminthosporol by: Shneider, Orel Svetlana. Published: (). Book Series Help; Contact Portal SYNTHESIS Full-text search Simple and Efficient Synthesis of N-Quaternary Salts of Quinuclidinium Derivatives Full Text Synthetic Studies towards the Total Synthesis of Providencin.

Some novel2,3-dioxo(substituted)arylpyrroles have been synthesized. Among these, pyrrolidine compound 1b was converted to 2,3-dioxoaryl pyrrolidine 2b. Finally a set of hydrazone derivatives was obtained from the reaction of 2b with various hydrazine salts.

The structures of all the new synthesized compounds were confirmed by elemental analyses, IR and 1H-NMR by: 9. A synthetic approach to the tunicamycins, a complex family of nucleosides with potent antibiotic and antiviral activities is reported based on diazo chemistry.

The corresponding precursors for the synthesis of tunicaminyl uracil derivatives, the non-stabilized diazo derived from and the aldehyde derivative.

Description Studies towards the total synthesis of lactacystin and its derivatives FB2

Lactacystin, a microbial natural product that inhibits cell proliferation and induces neurite outgrowth in a murine neuroblastoma cell line, has become a widely used reagent in functional studies of the proteasome, a high molecular weight, multicatalytic protease complex responsible for most non-lysosomal intracellular protein degradation.

Book Series Help; Contact Portal SYNLETT Full-text search Model Studies Towards the Total Synthesis of Pachylactone (N-Arylimino)-3,3,3-trifluoropropanoic Acid Esters Leading to Chiral 3,3,3-Trifluoroalanine and Its Derivatives Full Text.The positive identification of lactacystin as a potential neurotrophic factor, its appeal as a synthetic target and its scant supply made the -lactam an extremely hot target for total synthesis.

CoreyÂ’s First Total Synthesis of Lactacystin One year after muraÂ’s initial report, Corey published the first total synthesis of lactacystin.bioactivity of 1 over its congener omuralide (35 times more potent), its unique structure, comprising five contiguous stereogenic centers, encouraged several total synthesis efforts [14], structure activity relationship studies, [15 22] biosynthetic engineering, [23 27] and crystallographic studies with the yeast 20S proteasome [28].

Figure : Michael Groll, Henry Nguyen, Sreekumar Vellalath, Daniel Romo.